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Acknowledgments The authors wish to thank: Molly Migliorini and Dudley Strickland (Center for Vascular and Inflammatory Diseases Institute, University of Maryland School of Medicine, MD, United States) for the generous gift of purified RAP protein and antibodies to LRP1, CHO cell extracts used here, and advice on experimental design with the LRP1 studies

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Unsurprisingly, the industry related to preventing or covering up this loss of hair colour is estimated to be worth tens of billions of dollars globally a year, and the wild west that is social media has supercharged the number of people claiming their products can prevent or reverse early greying