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In a two-step procedure, 2-hydroxymalondialdehyde is firstly condensed with p -aminobenzoyl-L-glutamic acid, forming a diimine, which subsequently reacts with triamino-pyrimidinone to obtain folic acid

Liu W, Ge T, Leng Y, Pan Z, Fan J, Yang W, Cui R

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To address this inconsistency, we focus on two key mechanistic questions: (i) whether LMW thiols (e.g., GSH) can mediate disulfide bond reduction within 1,2-dithiolane scaffolds, and (ii) the structural determinants governing cargo release versus retention following LMW thiolmediated cyclic disulfide cleavage