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354 GLP-1RAs and musculoskeletal health GLP-1RAs and bone The quality of bone depends on bone metabolism, and the main factors affecting bone metabolism include osteoclasts, osteoblasts, and calcitonin

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Genetics: Variations in hormone receptor sensitivity and metabolic rate may affect response to triple agonist therapy, though evidence on genetic predictors is currently limited and emerging

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Unlike some peptides where receptor downregulation requires cycling, GLP-1 receptors don't follow the same pattern

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