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doi: 10.3389/fphar.2020.00967 Received 17 March 2020 Accepted 15 June 2020 Published 30 June 2020 Volume 11 - 2020 Edited by Keizo Kanasaki, Shimane University, Japan Reviewed by Shinji Kume, Shiga University of Medical Science, Japan

Importantly, GLP-1RAs do not exert direct immunosuppressive effects but instead modulate inflammatory pathways indirectly through metabolic and cellular mechanisms, supporting a favourable safety profile when used alongside bDMARDs

Several factors likely explain why Mazdutide produces fewer treatment-limiting side effects despite activating fewer receptors

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