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Estrogen can help keep inflammation down and joint tissues healthy, so the menopause transition can make your knees, hips, elbows, and shoulders more inflamed and damaged

Hormonal contraceptives and hormone replacement therapy can also influence risk, though the effect is variable and usually minor compared with other factors like antibiotics or diabetes

In addition, mass spectrometry analysis with electrospray ionisation revealed that the intracellular concentration of ZIL was 10 4 10 3 % (w/v) after 2 h of cultivation in 5% (w/v) ZIL solution, while the intracellular DMSO concentration was reported to be approximately 1.6% (w/v) after 2 h of cultivation in 7.8% (w/v) DMSO solution 14 , indicating that ZIL is a non-cell-permeable reagent

Each claimed benefit below is labeled by its evidence source so the reader can weigh it directly