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Dose schedule considerations by body weight The clinical trials used fixed doses (not weight-based dosing), which means a 200-pound person and a 300-pound person received the same milligram amount

To ensure optimal FcRn binding, cellular transport, and PK properties of albumin-based biologics, we attempted to substitute the C-terminal L585 of albumin with an amino acid residue that would not be recognized by CPA

Tail vein blood glucose was subsequently measured using a handheld glucometer (TheraSense Freestyle) at baseline and after 15, 30, 60 and 120 min

The abdomen typically provides the most consistent absorption for subcutaneous injections, though all approved sites are clinically effective when proper technique is used