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In practice, the phenolic OH groups in polyphenols act as reducing elements, but at the same time, when the phenoxyl radical is formed, they function as pro-oxidants, which supports from a theoretical point of view the fact that these compounds are activators of the Nrf2 factor, as they interact with the Keap1 protein

Steady-state plasma concentrations are reached by approximately week 4 to 6 of weekly dosing

Regulation of GPX3 Expression The human GPX3 gene spans approximately 8.4 kb, comprises five exons and is located on chromosome 5q33.1 [33,34] (Figure 2a)

10.1016/j.cmet.2014.09.018 46 ForetzM.GuigasB.ViolletB