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de Candia P, Spinetti G, Specchia C, Sangalli E, La Sala L, Uccellatore A, Lupini S, Genovese S, Matarese G, Ceriello A

That's hundreds of times more than any patch could realistically deliver through the skin, and berberine's molecular structure isn't ideally suited to transdermal absorption in the first place

The catch is, all these trials use different doses (from 300 to 1,500 milligrams per day) and duration (1 to 24 months), so its tough to know exactly what happens when you take berberine

It is a signal that deserves clinical attention, whether the cause is hormonal, neurochemical, nutritional, or some combination