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When combined with proper diet, regular exercise, and lifestyle modifications, retatrutide can help improve weight loss outcomes and treat comorbidities related to obesity such as diabetes or hypertension (high blood pressure)

this effect is linked to several mechanisms, including: triggering the release of leptin and peptide YY to signal a sensation of fullness and satiety 29 triggering the secretion of GLP-1 to increase feelings of satiety 30 slower digestion rate compared to other macronutrients Adequate protein intake while in a caloric deficit, either through the use of GLP-1 medications or adhering to a lower calorie diet, is essential for helping to protect lean body mass