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Depletion of the brain antioxidant glutathione (GSH) may be important in OS-mediated neurodegeneration, though studies of post-mortem brain GSH changes in AD have been inconclusive

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GPX3 mRNA is present in renal proximal tubular epithelial cells, and GPX3 may have specific antioxidant functions in the renal tubules or extracellular spaces due to the higher concentration of GSH in the kidneys