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doi: 10.1007/s00284-020-02053-9 330 TungJMDolovichLRLeeCH

Support detox pathways

In contrast, an aprotic solvent such as water can interact with the phenyl and carbonyl group of a flavonoid, and, depending on the pH, control its dissociation and thus its interaction with metal ions

The Potential M PRO Targets TXNRD1 and GCLC are Strongly Upregulated by Vitamin D3 In light of accruing evidence that vitamin D3 status is inversely correlated with severity of COVID-19 ( Vitamin D3-mediated activation of both TXNRD1 and GSH biosynthesis could substantially counteract the proteolytic knockdown of TXNRD1 and GCLC predicted by our hypothesis , which, if validated, would thus represent an important mechanism contributing to a role for vitamin D3 in moderating the severity of COVID-19