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Description IGF-1 LR3 (Long [Arg] Insulin-like Growth Factor-1) is a recombinant synthetic analog of human insulin-like growth factor 1, engineered with two structural modifications: an arginine substitution replacing glutamate at position 3 of the IGF-1 sequence (reducing IGFBP-3 binding affinity), and a 13-amino-acid N-terminal extension (Long peptide leader)

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Its concentration in human plasma is reported to decline substantially from young adulthood into later middle age, a decline that Pickarts later reviews use as the conceptual rationale for reintroducing the peptide