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Both metformin and Rybelsus aim to treat insulin resistance by increasing natural insulin secretion and reducing how much sugar your body releases

Lawmakers brought the modalities into the CLAA framework by adding the words cell or stem cell derived products, gene therapeutic products, and xenografts to multiple sections of the Drugs Rules, 1945, that previously referred to a narrower set of modalities including medicines based on recombinant DNA

In 2024, the FDA expanded the label to include reducing the risk of major cardiovascular events in adults with established cardiovascular disease and overweight or obesity based on the SELECT trial, which randomized 17,604 patients and showed a 20% reduction in major adverse cardiovascular events over a mean 40 months