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Taken together, the TME interferes with the oxidative metabolism of T cells through multiple pathways, preventing them from performing their effector functions and leading to dysfunction

The implementation of aerobic endurance training results in an elevation of shear stress and a chronic enhancement of flow-mediated stimuli, which in turn upregulate the expression of eNOS, increase capillary density, and augment mitochondrial oxidative capabilitytransformations that contribute to improved resting and exercise muscle perfusion as well as metabolic efficiency (18)

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