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Patients often prioritize outcomes such as: Daily functioning Fatigue Ability to work and maintain social activities Treatment convenience Emotional well-being Overall quality of life The integration of patient perspectives is helping create a more holistic understanding of treatment value and aligns closely with broader healthcare trends toward patient-centered and value-based care

Regarding study status, 120 studies (45.8%) were reported as completed, with a median study duration of 2.0 years (IQR 0.932.82)

Ongoing pressure keeps stress hormones elevated, which over time can affect sleep, digestion, blood pressure, and the immune system, so calming the mind alone is rarely enough

Rare reactions: Severe allergic responses, including anaphylaxis, are extremely uncommon