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Description

cAMP accumulation assay For GIPR, GLP-1R and GCGR, unimolecular agonist stimulated cAMP accumulation was measured by a LANCE Ultra cAMP kit (PerkinElmer)

SLC7A11 is a critical regulatory target involved in VRK2 regulating the GSH metabolic synthesis pathway Aforementioned data indicated that VRK2-deficient PC cells are vulnerable to GSH inhibition, this prompts us to explore the link between VRK2 and GSH metabolic synthesis pathway