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Although peptides have been used systemically for decades, their application in orthopaedicsparticularly for tendon healing, cartilage repair, and muscle recoveryhas only recently gained attention

The authors used non-obese diabetic (NOD) mice that are actually more a model for type 1 diabetes mellitus [11]

Indeed, a chronic dietary deficiency of these precursors leads to pellagra, which is characterized by diarrhea, dermatitis, dementia, neurological damage, and even death