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Preclinical studies generally support these clinical observations

Vitamins have excellent neuroprotective effects against the oxidative stress induced by metal and non-metals, and can protect against lead-induced neuronal apoptosis in rats (Khalil and Hussein, 2015), iron-induced oxidative stress in rat brain tissue (Sarkozi et al., 2016)

The researchers note that these differences may reflect species-specific factors, including drug administration routes, dosing, and diets, as well as differences in tolerance or drug clearance rates

Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate