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Yunfeng Liu, [email protected] These authors have contributed equally to this work and share first authorship These authors have contributed equally to this work This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology ORCID: Yi Zhang, orcid.org/0000-0003-0305-3127 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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It has not received a marketing authorisation from the MHRA, nor has it been recommended by the National Institute for Health and Care Excellence (NICE) for any clinical indication

premature discontinuation or suboptimal dosing prevents full therapeutic benefit