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While there is ongoing discussion about the balance and significance of the above mechanisms, it is clear that GLP-1 receptor agonists do reliably trigger weight loss, at least while people are taking the drug

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Doctors in the UK are expected to practice in line with evidence-based guidelines, but they must consider individual patient circumstances, local resources, and the specific guidance from their respective health systems

And the same mechanism that contributes to the reduced appetite that supports weight loss has recently been identified as having strong potential to disrupt the relationship between addiction, so much so as to reduce or altogether eliminate drug cravings