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Study 2: Selective Small-Molecule Inhibitors (including 5-Amino-1MQ) A selective, membrane-permeable NNMT inhibitor series decreased intracellular 1-MNA, increased NAD and SAM, suppressed adipocyte lipogenesis, and reversed high-fat-diet obesity in mice

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But those studies, McGuire says, dont have a lot of evidence behind them, and if you look on Reddit or other places where people are talking about it, he says, it appears that most people are recommending repeated doses