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Similarly, Adikwu and Bokolo 43 recorded a significant rise in MDA level and a significant decline in GSH level and SOD, CAT and GPx activities in the kidney tissue of MTX-treated rats, and they attributed these results to free radicals production, which might be the probable reason for the reduction of the anti-oxidant activities
These figures reflect the specific study population - patients who completed at least 365 days on the protocol - and may not represent real-world discontinuation patterns or outcomes for all patients who begin the program
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