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Pegylation extends half-life from 2 hours (native IGF-1 Ec) to 24+ hours, reducing injection frequency while maintaining safety profile similar to parent peptide

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No significant fluctuations were observed for the rest of the simulation period, with average RMSD values of 0.47 0.06, 0.58 0.04, and 0.48 0.12 for the nGLP1-DARPin, mGLP1-DARPin-1, and mGLP1-DARPin-2 complexed with HSA, respectively (Fig

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Nonsteroidal mineralocorticoid receptor antagonist Finerenone has recently been investigated in people with DKD (defined as an ACR of at least 3 mg/mmol and eGFR of 25 to 75 mL/min/1.73 m 2 ) who were treated with RAS inhibitors

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