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The Expert Committee observed that, Glucagon-like peptide-1 (GLP-1) receptor agonists can help people with type 2 diabetes especially those who also have heart or kidney disease by improving blood sugar control, reducing the risk of heart and kidney complications, supporting weight loss, and even lowering the risk of early death, WHO said in its official release

Its central mechanism of action provides pain relief with lower risks of stomach and cardiovascular problems compared to NSAIDs, though liver toxicity remains a serious concern with overdose or in susceptible individuals

This triple mechanism produces synergistic effects on appetite suppression, energy expenditure, and glucose metabolism that exceed single or dual agonists

International Journal of Biochemistry and Cell Biology, 42 (7), 11321141