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Gastroenterology 132:213157

doi: 10.1002/jcb.20116

Additionally, the role of host immune modulation in drug resistance requires further exploration, as studies suggest that resistant parasites alter host immune responses, though the molecular mechanisms remain poorly characterized (Costa-da-Silva et al., 2022)

These small molecule agonists increased insulin levels in primates but not rodents, which is explained by a cryo-EM structure that revealed a binding pocket requiring primate-specific tryptophan 33