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To test the effect of sustained repression of lipogenic programs and a concurrent sustained induction of NRF2 activity, we monitored mice for ten weeks following the induction of Gclc deletion alone (Gclc L-KO) or in combination with Nrf2 deletion (L-DKO) in the liver (Fig

doi: 10.7326/0003-4819-153-3-201008030-00005 98 HollanderPMaggsDGRugglesJAFinemanMShenLKoltermanOGet al

Meanwhile, the formed TeO 6 6- depletes the intracellular GSH and forms GSSG (Figure 1H)

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