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We acknowledge that using a quartile-based approach for the 1-star reduction could sometimes result in hospitals receiving a lower Overall Hospital Quality Star Rating even if overall performance improved

NCTC1469 cells, a normal mouse hepatocyte cell line, were obtained from the American Type Culture Collection and were cultured in DMEM containing 10% (v/v) fetal horse serum, 2 mM glutamine, 5 U/mL penicillin, and 50 g/mL streptomycin at 37 C in a humidified O 2 /CO 2 (19:1) atmosphere

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As a reduction of 0.5% in HbA1c is a clinically important difference (Zinman et al., 2018), a greater reduction by liraglutide may contribute to the renoprotective effects