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Type 2 diabetes mellitus A meta-analysis of 13 randomized, controlled feeding trials that substituted plant-derived PUFA (primarily linoleic acid [LA]) for saturated fatty acids or carbohydrates for 3 to 16 weeks in generally healthy adults showed a decrease in fasting insulin concentration and insulin resistance but no effect on fasting glucose concentration (123)

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However, when the investigational drug presents a higher level of risk for example in certain oncology settings, where the compound may be too toxic for healthy subjects the study may involve patients instead