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362 It is unclear whether the influence of APOEe4 may depend on the sex hormone estrogen

The rationale is that glucagon also increases energy expenditure and promotes hepatic fat mobilization, so a molecule that combines glucagons metabolic-rate effect with GLP-1/GIPs appetite-and-glucose control can, in principle, drive weight loss from both sides of the energy-balance equation at once

Do not combine these compounds without baseline bloodwork and regular monitoring

Improvement of Comorbidities: GLP-1 can also help to improve other health markers, such as blood pressure, cholesterol levels, and overall cardiovascular health