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J Cosmet Dermatol 16(2):253257 Zolghadri S, Beygi M, Mohammad TF, Alijanianzadeh M, Pillaiyar T, Garcia-Molina P et al (2023) Targeting tyrosinase in hyperpigmentation: current status, limitations and future promises

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Systemic actions: They are both found in several tissues, as well as in circulation, where they modulate metabolism, oxidative stress, cell survival, and inflammation