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You might wonder how a pill works if you lack intrinsic factor: at very high oral doses, a small amount of B12 can be absorbed directly through the gut wall via passive diffusion, bypassing the need for intrinsic factor entirely [1] [3]

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Lead induced decrease in brain Glutathione Peroxidase (GPx) activity may arise as a consequence of impaired functional groups such as GSH and Nicotinamide Adenine Dinucleotide Phosphate (NADPH) or selenium mediated detoxification of toxic metals