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Oral semaglutide generates higher rates of nausea (32-37% in STEP trials) compared to injected formulations because the medication contacts your esophagus and stomach lining directly, whereas subcutaneous injection bypasses the upper digestive tract entirely

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If you are a female reproductive potential: Zepbound may reduce the efficacy of oral hormonal contraceptives

Much of the initial skyrocketing demand for these products either branded or compounded that we saw a few years ago definitely seems to have been driven by celebrity use and viral social media posts