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In pivotal STEP trials, approximately 20-25% of semaglutide users reported diarrhea at some point during treatment, with most cases mild to moderate

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Participants switched to placebo after the run-in regained, with a body weight change of +6.9% from week 20 to week 68, versus 7.9% in those who continued

A 2025 orthopaedic sports medicine systematic review describes increasing use despite lack of FDA approval and bans in sport, and emphasizes that the evidence base is dominated by preclinical studies with limited high-quality human data