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In global clinical GLP-1 therapy guidelines, the 0.25 mg strength is strictly defined as the **initiation or starter phase**. It is not meant to serve as a long-term maintenance dose. The primary objective of this introductory volume is to gently introduce Semaglutide to your body's receptors. Patients typically remain on this baseline strength for exactly 4 weeks. Once a safe, comfortable tolerance is established, your healthcare provider will transition you to the next step-up dose (0.5mg) to steadily accelerate your weight loss momentum

The human body is usually quick to adjust, though, so these symptoms should fade soon afterward

Mozzafarian, et al

The Skinny on Tirzepatide & Semaglutide: What is Medical Weight Loss