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some studies suggest that pro-inflammatory cytokines IL-1 and TNF- suppress the expression of CYP7A1 and NTCP, leading to decreased BA synthesis and a reduction in the hepatic-enterohepatic circulation rate, thereby contributing to BA metabolic disorders

To understand why this pairing works, we first need to look at glutathione

Tan X, Jin P, Feng L, Song J, Sun E, Liu W et al (2014) Protective effect of luteolin on cigarette smoke extract-induced cellular toxicity and apoptosis in normal human bronchial epithelial cells via the Nrf2 pathway

Based on the Healing the Hidden Nerves protocol, here is how we break the NAD crisis: 1