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The other TRIUMPH trials, especially TRIUMPH-2 in type 2 diabetes and TRIUMPH-3 in sleep apnea, will feed into label breadth

recent studies show that locally secreted GLP-1 can activate GLP-1 receptor-expressing afferent fibers of the glossopharyngeal and vagal nerves, thereby transmitting peripheral gustatory information to the NTS

Similar concerns have been seen with lipid outcomes with an increase in total cholesterol after cessation of semaglutide to near pretreatment levels and loss of around two-thirds of the benefit in triglycerides, while positive changes in LDL-C and HDL-C were more modest but appeared more durable (Table 2) [73]