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Intriguingly, one of these studies also showed that longer administrations can lead to a normalization of anxiety and a dissociable improvement in depression-like behavior 158 a pattern that resembles of the mechanisms of action of conventional antidepressants and that may be further suggestive of the activity of GLP-1RAs on the serotonin system 158

Across the STEP trials, semaglutide 2.4 mg consistently demonstrated statistically and clinically significant weight loss compared with placebo [13, 38,39,40,41,42,43,44,45,46]

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It provides weight loss results of approximately 12.4% over 72 weeks