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Safety Concerns There have been reports of: Because of these problems, the FDA is stepping in

The mechanism likely involves both the direct mechanical benefit of reduced joint loading (less body weight pressing on the knee) and possible anti-inflammatory effects mediated through reductions in systemic inflammation a known consequence of significant weight loss and potentially enhanced by glucagon receptor-mediated metabolic improvements

Studies indicate that 86% of GLP-1 users do not meet daily protein requirements, consuming approximately 40g less protein than needed to preserve muscle mass