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Alanine mutations for four of the selected residues (Ile323, Val160, Gly151, and His363) were predicted to cause changes in the GLP-1R structure in the active state by altering the cavity or causing changes in exposed residues and breakages in salt bridges between residues, while a further three alanine mutated residues (Val229, Gly151, and His363) were predicted to cause changes in the inactive GLP-1R structure (Figure 2G)

Because each of the starting materials can be independently varied, it was possible to quickly produce a large library of these compounds

This means it acts on three receptors: GLP-1, GIP, and glucagon

Al crear una cuenta de cliente, usted proporciona al responsable del tratamiento la siguiente informacin: 3.1.2