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By concurrently modulating metabolic dysfunction and inflammatory signaling, GLP-1RAs could potentially reduce the required doses of biologics or other immunosuppressive therapies, thereby minimizing treatment-related toxicity while improving overall disease control
FFAR3 and FFAR2 are present on hormone-producing enteroendocrine cells (EECs): exposure to SCFAs stimulates EECs differentiation (71), and binding of SCFAs to FFAR3 and FFAR2 results in altered gene expression and secretion of gut hormones, such as peptide YY (PYY) and glucagon like peptide-1 (GLP-1) (72, 73)
Traditional chinese formula xiaoyaosan alleviates depressive-like behavior in CUMS mice by regulating PEBP1-GPX4-mediated ferroptosis in the hippocampus
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