This distinction matters clinically because it determines dosing, timing, and what results to expect at each stage of the protocol
(2018) 12:282/full
Considering millions of people are injecting B12, you get the idea how uncommon allergic reactions are
Classically, diabetic gastroparesis has been described as the slowing down of gastric motility in patients with diabetes, mainly associated with poorly controlled chronic hyperglycemia.20 Gastroparesis is defined as an abnormal delay in gastric emptying, in the absence of mechanical obstruction.21 Of the 30 to 50% of patients with longstanding diabetes, gastric emptying delay may or may not be associated with the gastrointestinal symptoms of nausea, vomiting, bloating, early satiety, and postprandial fullness.22,23 However, the presence of diabetic gastroparesis varies, according to the population analyzed and the diagnostic methods employed in each study.24 Acute dysglycemia Acute dysglycemia, i.e., acute episodes of either hyperglycemia or hypoglycemia, affect gastrointestinal motor function and intestinal sensitivity.25 Acute hyperglycemia has been associated with delayed gastric emptying or ileus.26 During episodes of diabetic ketoacidosis, 46% of patients present with abdominal pain, which, in large part, can be explained by gastric emptying delay and the electrolytic abnormalities the episodes tend to present with, such as hypokalemia
