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AMD: age-related macular degeneration AP-1: activator protein-1 BCL-2: B-cell lymphoma 2 COX: cyclooxygenase CYP2E1: cytochrome P450 2E1 DC: dendritic cell DHA: docosahexaenoic acid GITs: gastrointestinal tracts GPx: glutathione peroxidase GSH: glutathione GST: glutathione S -transferase HDL: high-density lipoprotein HO-1: heme oxygenase-1 IBD: inflammatory bowel disease IL-10: interleukin-10 iNOS: inducible nitric oxide synthase I-B: inhibitor of kappa B JAK: Janus kinase Keap1: Kelch-like ECH-associated protein 1 LDL: low-density lipoprotein LPS: lipopolysaccharide MDA: malondialdehyde MI: myocardial infarction MIAT: myocardial infarction associated transcript miR: micro-RNA NADPH: nicotinamide adenine dinucleotide phosphate NF-B: nuclear factor kappa B NOX: nicotinamide adenine dinucleotide phosphate oxidase Nrf2: nuclear factor erythroid 2-related factor 2 NSAIDs: non-steroidal anti-inflammatory drugs PC-3: prostate cancer cell line PI3K: phosphatidylinositol 3-kinase PPAR: peroxisome proliferator-activated receptor alpha RANKL: receptor activator of nuclear factor kappa B ligand ROS: reactive oxygen species RXR: retinoid X receptor alpha SOD: superoxide dismutase STAT: signal transducer and activator of transcription TG: triglycerides TNF-: tumor necrosis factor- The authors thank all colleagues who contributed to the preparation of this manuscript, providing support through its development, assisting in the formatting, and making final corrections

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For several additional loci, variants were either not present in the available summary statistics or did not reach statistical significance in the external datasets, although some demonstrated directionally consistent effects

GHK-Cu (50 mg) is listed for laboratory research use only