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In patients with chronic kidney disease, reduced reabsorption of carnitine can affect the availability of carnitine in muscles, leading to skeletal muscle atrophy and decreased exercise endurance [262]
10.1111/j.1463-1326.2010.01233.x 29
Clinical Interpretation This is gold-standard evidence
The peptide consists of 83 amino acids with a molecular weight of approximately 9.1 kDa, distinguished from native IGF-1 (70 amino acids) by two critical structural modifications: substitution of arginine for glutamic acid at position 3 and addition of a 13-amino acid extension at the N-terminus
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