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The precise physiological mechanisms responsible for heart rate elevation are not fully elucidated, but several hypotheses have been proposed: Sympathetic nervous system activation may occur as GLP-1 receptors are present in areas of the brain that regulate autonomic function

277,278,279,280 This effect is accomplished through the inhibition of JNK, NF-B, and other relevant signaling pathways

"And that inflammatory state results in organ damage that leads to cardiometabolic disease, kidney disease, diabetes, certain forms of cancer, and potentially certain neurodegenerative changes," says Kessler

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