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The HKL-2000 package (HKL Research Inc., Charlottesville, VA, USA) was used to index, integrate and scale the X-ray diffraction data (Table S2)

When the supercharged GLP-1 RAs enter the bloodstream and persist due to their prolonged half-life, they can activate these receptors in various locations, leading to a cascade of beneficial effects

The decision to use GLP-1 receptor agonists should be based on their licensed indications (diabetes or obesity management) rather than cholesterol lowering alone, with lipid improvements considered a beneficial additional effect within a comprehensive cardiovascular risk reduction strategy

Cell 153 , 14481460 (2013)