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Conclusions and future directions This review underscores the complex, bidirectional relationship between depression and diabetes, highlighting how each condition can exacerbate the other, complicating management and adversely impacting clinical outcomes

Riedl MA, Saxon A, Diaz-Sanchez D

The full details are in the Supplementary Material (Supplementary Table S1)

The bioavailability problem of berberine is widely recognized, and in the future its exact effect and long-term safety against DKD need to be more accurately assessed, and large-scale, high-quality preclinical and clinical studies must be conducted before clinical application