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The terminal half-life of methylene blue after intravenous administration is approximately 5.25 hours, but its effects can persist, necessitating ongoing observation

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The clinical presentation can vary widely depending on the type of mutation affecting SLC22A5 and the phenotypic manifestation of the mutation, i.e., age of onset, organ involvement, and severity of symptoms at the time of diagnosis (34)

19932023, [updated 2021 may 6]