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Here, we present combined pharmacokinetic and pharmacogenetic analyses in purely premenopausal breast cancer patient cohorts of different ethnic origin to evaluate (i) the factors that influence active tamoxifen metabolite concentrations with a particular emphasis on CYP2D6 and (ii) whether tamoxifen metabolite concentrations and/or genetic variants of drug-metabolizing enzymes (DME) are suitable biomarkers for the prediction of clinical outcome

Rabelink TJ, Koomans HA, Hen RJ, Dorhout Mees EJ (1990) Early and lateadjustment to potassium loading in humans

Many people misinterpret studies by not cross checking the units