doi: 10.3389/fphar.2025.1704083 Received 12 September 2025 Revised 16 December 2025 Accepted 18 December 2025 Published 21 January 2026 Volume 16 - 2025 Edited by Chen Ling, Fudan University, China Reviewed by Wentao Jia, Changhai Hospital, China Jie Cheng, Jiangsu University of Science and Technology, China Updates Copyright 2026 Li, Zhang, Li and Zheng
biochemically, there is intracellular glutathione (GSH) depletion and decreased activity of glutathione peroxidase 4 (GPX4), lipid peroxides cannot be metabolized by the GPX4-catalyzed reduction reaction, and Fe 2+ oxidizes lipids in a Fenton-like manner, resulting in a large amount of ROS, which promotes ferroptosis 3,6
71 NAD + in pluripotent and stem cells Somatic cells can acquire self-renewal capacity and other stem properties through dedifferentiation
Ive used the ghk-cu serum for the last 3 weeks, as directed