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Graphical abstract Similar content being viewed by others History and discovery of incretin action In 1902, the first hormone to regulate pancreatic exocrine secretion, secretin, was revealed [1]

Food and Drug Administration (FDA) approval, a quiet but consequential war is already being fought over who gets to manufacture it

Roche with its 2024 acquisition of Carmot, and Pfizer, following its 2025 acquisition of Metsera, enter obesity and broaden their presence in cardiovascular/metabolic, while other large pharmaceutical companies prepare to follow later in the decade

Semaglutide works in the gut like the bodys natural GLP-1, slowing digestion, curbing hunger, and signaling fullness to the brain